Proteolytic processing of Alzheimer’s β-amyloid precursor protein
نویسندگان
چکیده
منابع مشابه
Proteolytic processing of the amyloid- protein precursor of Alzheimer’s disease
The proteolytic processing of the amyloidprotein precursor plays a key role in the development of Alzheimer’s disease. Cleavage of the amyloidprotein precursor may occur via two pathways, both of which involve the action of proteases called secretases. One pathway, involving and -secretase, liberates amyloidprotein, a protein associated with the neurodegeneration seen in Alzheimer’s disease. Th...
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specific functions. Notch itself is a single-pass transTwo seemingly unrelated avenues of research, Alzheimembrane receptor with large extracellular and intracelmer’s disease and developmental cell fate specification, lular domains (Figure 1A). During receptor maturation, have intersected at the presenilin and Notch genes. ReNotch is cleaved in its extracellular domain by furin or a cent report...
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The amyloid β-protein (Aβ) is subject to proteolytic degradation by a diverse array of peptidases and proteinases, known collectively as Aβ-degrading proteases (AβDPs). A growing number of AβDPs have been identified, which, under physiological and/or pathophysiological conditions, contribute significantly to the determination of endogenous cerebral Aβ levels. Despite more than a decade of inves...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2011
ISSN: 0022-3042
DOI: 10.1111/j.1471-4159.2011.07519.x